Study sheds light on contrast-induced nephropathy in high-risk patients

August 8, 2008 Study sheds light on contrast-induced nephropathy in high-risk patients H. A. Abella -------------------------------------------------------------------------------- Researchers have established the safety of nonionic contrast media in adult and pediatric patients, but questions remained regarding the use of low- and iso-osmolar agents, particularly in patients at high risk of developing contrast-induced nephropathy. Now results from a prospective multicenter study done in China and the U.S. suggest that risk is equally low with either type of agent. For some time, the use of nonionic low-osmolar contrast media has been deemed as generally safe in patients at high risk for CIN. The clinical literature, however, lacked weighty data comparing low- and iso-osmolar agents in patients with preexisting renal dysfunction and diabetes, two of the strongest independent predictors of the condition.

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