Prostate MR meets challenge following ultrasound ablation

August 1, 2008 Diagnostic Imaging. Prostate MR meets challenge following ultrasound ablation Dynamic contrast enhancement offers better sensitivity, but diffusion-weighted imaging turns in higher specificity -------------------------------------------------------------------------------- High-intensity focused ultrasound ablation is used to manage localized prostate cancer after external-beam radiation therapy. But post-treatment alterations to prostate zonal anatomy hamper the assessment of local tumor progression that influences decisions about second-line treatment. An interdisciplinary group from Sungkyunkwan University School of Medicine and Kangwon National University School of Medicine in South Korea tested two MR techniques for predicting local tumor progression. Twenty-seven patients underwent transurethral prostate resection and endorectal HIFU. These patients had clinical stage T1-T2 disease, no evidence of metastases, and a pre-ablation mean prostate-specific antigen level of 7.25 ng/mL. PSA levels continued to rise after treatment. Prostate MRI was done on a 3T system with two readers independently reviewing the MR images.

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