Breast MR imaging aids high-risk women

January 22, 2008 Diagnostic Imaging. Breast MR imaging aids high-risk women Once again, MRI has outrun other modalities as a supplemental tool for screening high-risk women. Emily Hayes -------------------------------------------------------------------------------- A large prospective screening trial from the University of Pennsylvania compared screen-film mammography, digital mammography, whole-breast ultrasound, and contrast-enhanced MRI in a population of 569 asymptomatic women. In this single-center trial, funded by the National Cancer Institute, the definition of high risk included women with a 25% lifetime risk based on genetic testing or Gail or Claus models and those with a history of cancer in the contralateral breast. Of 95 lesions recommended for biopsy, 11 were malignant (11.6%). Seven of the 11 cancers were seen on only one modality: one with digital mammography and six with MRI alone. No cases were seen on either screen-film mammography or ultrasound alone.

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