Vertebroplasty proves no better for pain than placebo in two groundbreaking trials

Interventional radiologists are coming to grips with the implications of two groundbreaking clinical trials indicating that vertebroplasty relieves pain from osteoporotic vertebral fractures no better than a sham version of the procedure. Results from Mayo Clinic in Rochester, MN, and Cabrini Medical Center in Malvern, Australia, were published simultaneously Aug. 5 in the New England Journal of Medicine. Unlike past trials that examined only treated patients, the Mayo and Cabrini studies compared results from patients who underwent vertebroplasty with patients who were randomly selected to receive sham interventions.

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