Trial finds perfusion-diffusion mismatch can expand time available for tPA stroke treatment

February 27, 2008 Trial finds perfusion-diffusion mismatch can expand time available for tPA stroke treatment H. A. Abella -------------------------------------------------------------------------------- Results of a much-anticipated study gauging tissue plasminogen activator's impact on acute stroke patients with MRI-diagnosed penumbra mismatch suggest it is effective up to six hours after the onset of stroke and its administration could lead to improved clinical outcomes in some patients. Stroke researchers have invested years investigating the value of diffusion- and perfusion-weighted MR imaging in patients with acute stroke. A large subset of these patients reveal a perfusion-diffusion mismatch of their DWI/PWI images. Previous studies have suggested that the area represented by this mismatch could consist of potentially salvageable tissue.

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