Report from ISMRM: Prostate imaging studies weigh diagnostic power of MRI methods

May 7, 2008 Report from ISMRM: Prostate imaging studies weigh diagnostic power of MRI methods -------------------------------------------------------------------------------- A clinical trial presented Monday demonstrated how complicated the quantification of dynamic contrast-enhanced MRI of suspected prostate cancer can be. Investigators hold great hope for DCE-MRI for this application because of the insensitivity of contrast-enhanced T2-weighted imaging and the considerable convenience of performing DCE-MRI without the need for an endorectal coil. Presenter Guang Jia, a research student at Ohio State University, and colleagues under the direction of Dr. Michael Knopp evaluated 27 patients who were awaiting robotic prostatectomy for clinically proven prostate cancer. DCE-MRI was performed on a 3T Philips Achieva scanner using an eight-channel phased-array coil. Several semiquantitative parameters were calculated from the dynamic contrast data and compared with stained histological samples of the removed prostate and seminal vesicles. Regions of interest were drawn to identify cancerous regions, including tumor in the peripheral and transition zone, the noncancerous peripheral zone, and the central gland with benign prostate hyperplasia, muscle, and neurovascular bundle.

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