PWI/DWI brain mismatch widens stroke window

May 1, 2008 Diagnostic Imaging. PWI/DWI brain mismatch widens stroke window H. A. Abella -------------------------------------------------------------------------------- Results of the EPITHET trial indicate MRI perfusion-diffusion mismatch can add a crucial three extra hours for safe administration of tissue plasminogen activator (tPA) to treat qualified acute stroke patients. The phase II Echo­planar Imaging Thrombolytic Evaluation Trial involved 101 patients with acute ischemic stroke at 15 sites in Australia, New Zealand, Belgium, and Scotland. They all arrived in the emergency room more than three hours after symptom onset, which would usually disqualify them for clot-busing tPA treatment.

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