Proton MRS links fibromyalgia pain to changes in brain molecule

April 10, 2008 Proton MRS links fibromyalgia pain to changes in brain molecule Yomi Wrong -------------------------------------------------------------------------------- Widespread muscle and tissue pain, tenderness, and fatigue are well-documented symptoms of fibromyalgia, a chronic condition that affects up to an estimated 6% of the U.S. population. The underlying pathology of the pain disease is unknown. A new study featuring proton MR spectroscopy, however, has found a key linkage between the pain and a specific brain molecule. Researchers at the University of Michigan Health System found pain in patients with fibromyalgia decreased when levels of glutamate went down. The main strength of the study was a novel approach using proton MR spectroscopy (H1-MRS) to obtain insight into brain metabolism.

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