PET tops CT for early characterization of malignant lung nodules

April 11, 2008 PET tops CT for early characterization of malignant lung nodules H. A. Abella -------------------------------------------------------------------------------- A large multicenter trial rates FDG-PET as more reliable than CT for the detection of malignant solitary pulmonary nodules. The findings suggest, however, that a combined rather than single-modality approach may lead to earlier treatment and help avoid invasive procedures. The clinical literature notes that suspicious lung nodules appear frequently as incidental findings on chest radiography or CT. These cases are usually followed up with PET or CT to characterize lesions as benign or malignant. Most studies done to evaluate CT's accuracy in this setting, however, have been performed with outdated technology, while PET studies have typically included small patient cohorts of questionable statistical merit.

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