Ground-glass nodules merit scrutiny for differential diagnosis

May 16, 2008 Ground-glass nodules merit scrutiny for differential diagnosis Shalmali Pal -------------------------------------------------------------------------------- Persistent ground-glass nodules in the lungs are worth a closer look, as they are highly associated with malignancy. Dr. Anne Leung offered an overview of how these lesions present on CT imaging at the 2008 Stanford International Symposium on Multidetector-Row CT in Las Vegas. "Ground glass is defined as hazy or decreased attenuation on CT that does not obscure underlying bronchovascular bundles," said Leung, chief of thoracic imaging at Stanford University School of Medicine. "The pathologic correlates that have been described with ground-glass nodules are partial airspace filling, interstitial filling, edema, fibrosis, and neoplastic infiltration." Leung pointed out that ground-glass nodules have two subtypes: pure ground glass and ground glass with solid components. Ground-glass nodules with solid elements are more likely to be malignant, particularly if they persist over three months, she said.

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