Controversy dogs lung screening clinical trials

July 1, 2008 Diagnostic Imaging. Controversy dogs lung screening clinical trials By Shalmali Pal -------------------------------------------------------------------------------- Despite setbacks in the laboratory and the press, multislice CT as a possible screening test for lung cancer continues to provoke strong interest in anticipation of findings from randomized multicenter clinical trials that may ultimately judge its value. The screening protocol has been controversial since Weill Cornell radiologist Dr. Claudia Henschke first launched the International Early Lung Cancer Action Program (I-ELCAP) for CT cancer screening in 2000. Henschke's initial results for the detection of stage I lung cancers appeared promising, but the possibility of high false-positive results encouraged Dr. Stephen Swensen, radiology chair of the Mayo Clinic in Rochester, MN, to question her approach.

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