Advanced pathology techniques challenge notions about breast cancer

March 5, 2008 Advanced pathology techniques challenge notions about breast cancer Emily Hayes -------------------------------------------------------------------------------- Cutting-edge pathology techniques will demonstrate the true nature of breast cancer during the opening session of a categorical course Friday afternoon. Rare and potentially revolutionary, the new methods look set to challenge radiologists' understanding of breast cancer and could alter their approach to imaging interpretation. Of thousands of pathology departments in the world, only a handful use "large-format pathology" in the breast. With large-format pathology, bigger continuous pieces of tissue are examined on supersized microscope slides with sophisticated 3D histology techniques. Whether conventional or advanced histology techniques are used, awareness is growing of the importance of cooperation between radiologists and pathologists in breast cancer management. These doctors must work closely together to match up pathology results with 2D and 3D imaging studies, make an assessment about the extent of disease, and provide accurate information for their colleagues in surgery. One course presenter, Dr. Tibor Tot, is a pioneer in large-format pathology, having almost 20 years of experience in the field. He recently published results from 500 consecutive breast carcinoma cases, reporting that only 34% of cases were unifocal, 36% were multifocal, and the others were diffuse or mixed (Cancer 2007;110:2551-2560). In contrast, conventional 2D pathology techniques have indicated the majority of breast cancer cases are unifocal. "You see a microscopic tumor and believe there is only one focus, that the breast carcinoma is only a lump -- and that is wrong," said Tot, head of pathology and clinical cytology at the Central Hospital in Falun, Sweden. Information about disease extent has obvious importance for planning surgery. A lump can be excised in a lumpectomy, but breast-conserving surgery may not be appropriate for multifocal disease, given the frequency of post-treatment relapses. Instead, mastectomy may be a better option. Tot said that in his region, mastectomy is more common than in other settings because advanced pathology, which indicates more extensive disease, is routinely used. The large-format pathology findings match well to 3D imaging studies such as MRI, which also helps to show the true extent of disease. Researchers at Italy's University of Bologna, where large-format histology has been used in the breast for about seven years, recently reported that more than 50% of in situ and invasive lobular disease findings in 45 mastectomy cases was multifocal (Human Pathol 2007;38[12]:1736-1743). "Their results, similar to ours, show that multifocality and extensive lesions are very common in breast cancer. If an invasive tumor is multifocal, it has double the potential to give lymph node metastases," Tot said. The Italian researchers also noted that well-differentiated ductal carcinoma in situ grade 1 is often multifocal, while poorly differentiated DCIS grade 3 is more commonly unifocal. Tot speculates that breast disease often involves development of multiple foci in one sick lobe and that partial mastectomy to remove the sick lobe may be a viable option in these cases (Int J Surg Pathol 2007;15[4]369-375). According to this theory, it may be possible to prevent development of cancer in the future by removing a sick lobe before cancer develops. During the same session, Dr. Daniel Faverly will explain the microanatomy of the breast, including the significance of the terminal ductal lobular unit for breast imaging analysis, based on his experience with large-format pathology and conventional pathology techniques.

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